Opportunities for cellular rejuvenation in Alzheimer’s disease: how epigenetic reprogramming and chaperone-mediated autophagy are enabling next generation therapeutic approaches. Rosenzweig-Lipson, S. The Journal for Prevention of Alzheimer’s Disease. 2023 October 24; 10, 661–668.
Our Science
Publications
Scientists at Life Biosciences regularly publish articles in peer-reviewed journals and publications to inform the scientific community of our research and to contribute to the advancement of research in the field of aging.
Partial Epigenetic Reprogramming
Loss of epigenetic information as a cause of mammalian aging. Yang J, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Ching Chew Y, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O’Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Cell. 2023 January 19; 186;2, 305-326.
Reprogramming to recover youthful epigenetic information and restore vision. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang J-H, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Nature. 2020 December 2; 588, 124–129.
In vivo amelioration of age-associated hallmarks by partial reprogramming. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Esteban CR, Nuñez G, Delicado EN, Campistol JM, Guillen I, Guillen P, Belmonte JCI. Cell. 2016 December 15; 167:7, 1719-1733.
Chaperone-Mediated Autophagy
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Gomez-Sintes R, Xin Q, Jimenez-Loygorri J, McCabe M, Diaz A, Garner T, Cotto-Rios X, Wu Y, Dong S, Reynolds C, Patel B, de la Villa P, Macian F, Boya P, Gavathiotis E & Cuervo AM. Nat Commun. 2022 July 21; 13, 4220.
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Cell. 2021 May 13; 184:10, 2525–2796.
Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Dong S, Wang Q, Kao Y-R, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D’Alessandro A, Will B, Cuervo AM. Nature. 2021 January 13; 591, 117–123.
Selective autophagy as a potential therapeutic target for neurodegenerative disorders. Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. The Lancet. 2018 September 1; 17:9, 802–815.
The coming of age of chaperone-mediated autophagy. Kaushik S, Cuervo AM. Nat Rev Mol Cell Biol. 2018 April 6; 19, 365–381.
Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Nat Chem Biol. 2013 18 October; 9, 374–382.
Balance between autophagic pathways preserves retinal homeostasis. Rodríguez-Muela N, Koga H, García-Ledo L, de la Villa P, de la Rosa EJ, Cuervo AM, Boya P. Aging Cell. 2013 22 March; 12:3, 478-488.
Reviews
Opportunities for cellular rejuvenation in Alzheimer’s disease: how epigenetic reprogramming and chaperone-mediated autophagy are enabling next generation therapeutic approaches. Rosenzweig-Lipson, S. The Journal for Prevention of Alzheimer’s Disease. 2023 October 24; 10, 661–668.
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