Scientists now understand the major causes of aging and how to treat them.

the 8 components of aging and our companies

Life Biosciences is tackling all eight components of aging.

Click on the component to see where each of our companies is focused.

Altered Communication & Inflammation

Spotlight Biosciences, Inc.

Using proprietary technologies, Spotlight has developed a platform that enables the identification and quantification of thousands of novel peptides, some of which have unique biology relevant to treating human diseases and aging. Drs. David Sinclair and Bogdan Budnik co-founded the company out of Harvard Medical School.

Chromosomal Instability

Jumpstart Fertility, Inc.

During aging, the process by which “spindles” attach to and pull chromosomes apart can go awry. When this happens, egg cells can have an uneven number of chromosomes, a common cause of infertility.  Co-founders Drs. Lindsay Wu and Hayden Homer are developing the world’s first drug to improve egg cell quality and restore fertility in women of advancing age or who have experienced premature infertility. The benefits of these molecules may go well beyond reversing aging in the egg.

Cellular Senescence

Senolytic Therapeutics, Inc.

Senolytic Therapeutics is developing new compounds that specifically target old, senescent cells for destruction.  Using proprietary strategies to target senescent cells, co-founders Drs. Manuel Serrano and Marc Ramis Castelltort, are advancing therapies to treat biological aging and associated diseases.

Loss of Proteostasis

Selphagy Therapeutics, Inc.

Autophagy is the process by which young cells recycle “junk”. Selphagy is developing the first drugs that restore autophagy during old age and in rare diseases where it may not function properly – so-called “lysosomal storage diseases”. Co-founded by Drs. Ana Maria Cuervo and Evris Gavathiotis,  Selphagy has identified new chemical entities with a molecular target to activate autophagy.

Metabolism

Continuum Biosciences, Inc.

Scientists from Continuum have discovered self-limiting uncouplers that are highly specific to mitochondria.  Co-founders Drs. Kyle Hoehn and Webster Santos are working with their team to fine-tune the effectiveness of their compounds to address obesity, diabetes, liver disease and other secondary conditions.

Stem Cell Exhaustion

Senolytic Therapeutics, Inc.

Senolytic Therapeutics is developing new compounds that specifically target old, senescent cells for destruction.  Using proprietary strategies to target senescent cells, co-founders Drs. Manuel Serrano and Marc Ramis Castelltort, are advancing therapies to treat biological aging and associated diseases.

Epigenetic Alterations

Jumpstart Fertility, Inc.

During aging, the process by which “spindles” attach to and pull chromosomes apart can go awry. When this happens, egg cells can have an uneven number of chromosomes, a common cause of infertility.  Co-founders Drs. Lindsay Wu and Hayden Homer are developing the world’s first drug to improve egg cell quality and restore fertility in women of advancing age or who have experienced premature infertility. The benefits of these molecules may go well beyond reversing aging in the egg.

Mitochondrial Dysfunction

Continuum Biosciences, Inc.

Scientists from Continuum have discovered self-limiting uncouplers that are highly specific to mitochondria.  Co-founders Drs. Kyle Hoehn and Webster Santos are working with their team to fine-tune the effectiveness of their compounds to address obesity, diabetes, liver disease and other secondary conditions.

  • Altered Communication & Inflammation

    Blood from young animals can restore the health of aged animals. Conversely, the blood from aged animals can make young animals old. Likely causative agents are cell-to-cell communication proteins called hormones and inflammatory cytokines. Not all these proteins in human blood have been identified, and their discovery could lead to new treatments for rare and common diseases, as well as aging itself.

  • Chromosomal Instability

    Our DNA is packed into structures called chromosomes, with exactly 46 chromosomes inside every human cell. Before cells divide, they create exact replicas of their chromosomes, which are then divided equally so that each new cell has the same number as the original cell it came from. As we age, our cells lose the ability to accurately separate chromosomes during cell division. Cells that then carry the wrong number of chromosomes can cause cancer, infertility and aging.

  • Cellular Senescence

    When cells become damaged or stop working, they die and are replaced by new, healthy cells. As we grow old, the body is unable to clear “senescent cells”.  Senescent cells are like zombies: they should be dead but they survive and cause havoc. In critical organs and tissues they secrete factors that inflame healthy cells and induce cancer. Removing senescent cells could treat numerous age-related diseases, and potentially reverse aspects of aging.

  • Loss of Proteostasis

    Proteins are delicately folded machines that keep our cells running. If these machines become unfolded, they can’t do their job properly and can become tangled with each other to form clumps. Normally the cell has the ability to destroy and recycle these tangled proteins, but as we age they can’t do this as efficiently. Agents that boost proteostasis could be used to treat a variety of diseases including both rare and neurodegenerative diseases, as well as aging.

  • Metabolism

    Diet and exercise are the strongest interventions we have for maintaining health. As we age, our bodies burn fuel at a slower rate, leading to the accumulation of fat, which accelerates diseases such as diabetes, infertility, fatty liver diseases and obesity, as well as aging itself. Restoring the ability of our bodies to efficiently burn calories is one of the most promising ways to treat metabolic diseases and extend our healthy years.

  • Stem Cell Exhaustion

    Stem cell exhaustion results in the inability of our organs to replenish themselves with fresh cells to maintain health and vigor. Replacing stem cells or restoring the youthfulness of existing stem cells could be used to treat rare diseases, worn out body parts, and to slow aging.

  • Epigenetic Alterations

    DNA exists in almost every cell in the body. Only a portion of our DNA needs to be turned on to make a particular cell type, such as a liver or brain cell. The cell controls which genes are turned on and off by wrapping DNA into tight balls around proteins, like balls of string. When we age, DNA unwinds from these tight balls and starts to turn on genes that shouldn’t be turned on. Restoring the epigenome could have radically positive effects on human health and lifespan.

  • Mitochondrial Dysfunction

    Mitochondria are the internal combustion engines of the cell. They turn food into chemical energy. When they malfunction, it is like a car engine that leaks toxic, half-burned gasoline into the passenger compartment. As we age, mitochondria increasingly malfunction. As a result, the energy we consume is turned into lipids that inflame our tissues, while mitochondria leak free-radicals into the surrounding cell, causing damage.