Our Innovative Companies

Life Biosciences is made up of a family of companies which will continue to expand in the future. Click on each company below to learn more about it.

Selphagy Therapeutics  |  Boston; New York

Autophagy is the process by which young cells recycle “junk.” Selphagy is developing the first drugs that restore autophagy in so-called “lysosomal storage diseases” during old age.  Co-founded by Drs. Ana Maria Cuervo and Evris Gavathiotis, Selphagy has identified new chemical entities with a molecular target to activate autophagy.

Aging Component: Loss of Proteostasis

Developing ways to boost the body's ability to remove damaged and misfolded proteins that are believed to cause aging. The technology has applications in treating vision loss, Alzheimer's and rare genetic diseases.

Senolytic Therapeutics  |  Boston; Barcelona  |  Website

Senolytic Therapeutics is developing new compounds and technologies that specifically target “zombie” senescent cells for destruction.  Using proprietary strategies to target these cells, co-founders Drs. Manuel Serrano and Marc Ramis Castelltort are advancing therapies to treat biological aging and associated diseases.

Aging Component: Cellular Senescence

Developing unique approaches to kill off "zombie" or senescent cells in the body, which are believed to underlie the aging process.

Aging Component: Stem Cell Exhaustion

Developing ways to remove senescent cells and allow stem cells to expand and renew tissues.

Jumpstart Fertility, Inc.  |  Boston; Sydney

Drs. Lindsay Wu and Hayden Homer are developing medicines intended to improve egg cell quality and restore fertility in women of advancing age or who have experienced premature infertility. These molecules may go well beyond improving fertility.

Aging Component: Chromosomal Instability

Focused on how to prevent DNA damage and reverse aging in the ovary, potentially restoring a woman's ability to produce healthy, viable eggs.

Aging Component: Epigenetic Alterations

Developing medicines that restore a more youthful "epigenome" to improve egg cell quality in the female reproductive system to reverse infertility.

Continuum Biosciences  |  Blacksburg, VA; Sydney  |  Website

Scientists from Continuum have discovered self-limiting uncouplers that are highly specific to mitochondria.  Co-founders Drs. Kyle Hoehn and Webster Santos are working with their team to fine-tune the effectiveness of their compounds to address obesity, diabetes, liver disease, and other conditions that decrease lifespan.

Aging Component: Mitochondrial Dysfunction

Developing new molecules that restore the metabolic engine of the aged cell, thereby reducing damage from free-radicals.

Aging Component: Metabolism

Taking a fresh look at metabolic diseases. By forcing the cell to use more nutrients to produce the same amount of energy, they can induce fat loss and potentially treat metabolic diseases such as type 2 diabetes.

Animal Biosciences  |  Boston  |  Website

We are researching new compounds for veterinary use, and aim to develop proven treatments to prolong youth and expand the lifespan of our four-legged friends, because we believe animals deserve to be beneficiaries of our sophisticated research and we will gain insights applicable to the work of our Daughter companies.