the Entirety of Healthspan Research

We are tackling each of the eight hallmarks of aging. In fact, some of our Daughter companies are addressing more than one, based on the nature of their research. Click on Read each hallmark to learn more about it, and where our research is headed.

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Mitochondrial Dysfunction
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Altered Communication & Inflammation
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Chromosomal Instability
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Cellular Senescence
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Loss of Proteostasis
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Epigenetic Alterations
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Stem Cell Exhaustion
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Metabolism
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All 8

the 8 components of aging and our companies

Life Biosciences is tackling all eight components of aging.

Reach each hallmark to see where each of our companies is focused.

  • Mitochondrial Dysfunction

    Mitochondria are the internal combustion engines of the cell, turning food into chemical energy. When they malfunction, it’s like a car engine that leaks toxic, half-burned gasoline into the passenger compartment. As we age, mitochondria increasingly malfunction. As a result, the energy we consume is turned into lipids that inflame our tissues, while mitochondria leak free-radicals into the surrounding cell, causing damage.
  • Altered Communication & Inflammation

    Blood from young animals can restore the health of aged animals, and vice versa. Likely causative agents are cell-to-cell communication proteins called hormones and inflammatory cytokines. Not all these proteins in human blood have been identified, and their discovery could lead to new treatments for rare and common diseases, as well as aging itself.
  • Chromosomal Instability

    Our DNA is packed into exactly 46 chromosomes inside every human cell. Before cells divide, they create replicas of their chromosomes, which are then divided equally so that each new cell has the same number as the original cell it came from. As we age, our cells lose the ability to accurately separate chromosomes during cell division. Cells that then carry the wrong number of chromosomes can cause cancer, infertility and aging.
  • Cellular Senescence

    When cells become damaged or stop working, they die and are replaced by new, healthy cells. As we grow old, the body is unable to clear “senescent cells.”  Senescent cells are like zombies: they should be dead but they survive and cause havoc. In critical organs and tissues they secrete factors that inflame healthy cells and induce cancer. Removing senescent cells could treat numerous age-related diseases, and potentially reverse aspects of aging.
  • Loss of Proteostasis

    Proteins are delicately folded machines that keep our cells running. If these machines become unfolded, they can’t do their job properly and can become tangled into clumps. Normally the cell has the ability to destroy and recycle these tangled proteins, but as we age they can’t do this as efficiently. Agents that boost proteostasis could be used to treat a variety of diseases including both rare and neurodegenerative diseases, as well as aging.
  • Epigenetic Alterations

    DNA exists in almost every cell in the body. Only a portion of our DNA needs to be turned on to make a particular cell type, such as a liver or brain cell. The cell controls which genes are turned on and off by wrapping DNA into tight balls around proteins, like balls of string. When we age, DNA unwinds from these tight balls and starts to turn on genes that shouldn’t be turned on. Restoring the epigenome could have radically positive effects on human health and lifespan.
  • Stem Cell Exhaustion

    Stem cell exhaustion results in the inability of our organs to replenish themselves with fresh cells to maintain health and vigor. Replacing stem cells or restoring the youthfulness of existing stem cells could be used to treat rare diseases, worn out body parts, and to slow aging.
  • Metabolism

    Diet and exercise are the strongest interventions for maintaining health. As we age, our bodies burn fuel at a slower rate, leading to the accumulation of fat, which accelerates diseases such as diabetes, infertility, fatty liver diseases and obesity, as well as aging itself. Restoring the ability of our bodies to efficiently burn calories is one of the most promising ways to treat metabolic diseases and extend our healthy years.